Fluticasone
Medication Facts
- Performance enhancing
- No
- Total hours to clear
- 48
- Frequently used
- Most Prescribed
- ESC ID
- FLUTI-0420
- Trade names
- Flovent
- Drug type
- Corticosteroid / Glucocorticoid
- Plasma half-life · hours
- Not Publshed
- Equine dosing
- 1 to 6 mcg/kg (or a flat dose of 1,000 to 3,000 mcg per horse) inhaled via an equine-specific aerosol mask system twice daily. Therapy is usually tapered over several weeks once clinical improvement is seen. This may be used with Albuterol nebulizer with no withdraw - consult with veterinarian.
- Cmax · peak plasma concentration
- 10-50 pg/mL
- Tmax · time to peak plasma concentration
- Not recorded
- ESC concentration guidance
- CMAX or 100% of Efficacy
- Primary withdrawal · hours
- 0
- Washout withdrawal · hours
- 0
- ESC control type
- A1 - Generally Controlled - Therapeutic
- Medication report required
- Generally not required, however understand exceptions.
Uses & side effects
Chronic asthma managment
Product-specific side effects await source review.
Drug interactions
In horses, direct systemic drug interactions with inhaled fluticasone propionate are generally low because very little of the drug enters the bloodstream. However, caution is required when combining it with systemic corticosteroids, potent CYP3A4 liver enzyme inhibitors (like ketoconazole), or live vaccines and local immunosuppressive therapies.Important Considerations and InteractionsSystemic Corticosteroids: Combining inhaled fluticasone with systemic steroids (such as oral prednisone or injectable/oral dexamethasone) increases the risk of hypothalamic-pituitary-adrenal (HPA) axis suppression and systemic side effects like lethargy or laminitis risk, though less than systemic-only regimens.Liver Enzyme Inhibitors: Drugs that slow down liver metabolism (such as ketoconazole) can theoretically increase systemic accumulation if any swallowed portion of the inhaled drug is absorbed.Active Infections: Using fluticasone in horses with untreated bacterial, viral, or fungal respiratory infections can worsen the infection due to local immune suppression in the airways.Not a Rescue Drug: Fluticasone is a slow-acting maintenance controller for equine asthma (RAO/IAD) and should not be relied upon alongside or instead of acute bronchodilators during an emergency bronchospasm.
Contraindications
Corticosteroids (prednisone, dexamethasone), may cause active infections to worsen, ketoconazole, liver enzyme inhibitors