Equine Sports Council

Controlled Medications Library

ESC MEDICATION CLASSIFICATIONClass C1 - Strictly Controlled - PE Medical

ESC Medication Library · Revision 4

← Medication library · Compare sanctioning bodies

Medication Facts

Performance enhancing
Conditionally
Total hours to clear
Not recorded
Frequently used
Most Prescribed
ESC ID
TRIHIS-0888
Trade names
Neogen Vet
Drug type
Antihistamine, Decongestant
Plasma half-life · hours
Not Published
Equine dosing
1/2 ounce per 1000 pounds (1 scoop) of granuals with food every 12 hours
Cmax · peak plasma concentration
Unavailable
Tmax · time to peak plasma concentration
Unavailable
ESC concentration guidance
May not exceed (LDL) Lowest Detectable Level of .05 ng/mL or 50 picograms per mL
Primary withdrawal · hours
24
Washout withdrawal · hours
72
ESC control type
C1 - Strictly Controlled - Restricted - Performance
Medication report required
MED REPORT REQUIRED

Uses & side effects

Frequenty Used

Drug interactions

Antihistamines in horses, such as cetirizine and tripelennamine, commonly interact with CNS depressants (sedatives like acepromazine) to cause increased sedation, ataxia, or excitement. Ivermectin, if given 12 hours before cetirizine, significantly increases its concentration, while corticosteroids can mask allergic skin test results

Contraindications

Clenbuteral, Albuterol, Salbutamol, Ventipulmen, Tri-Hist

Government Numbers

Neogen Tri-Hist Granules, product 08874; 20 oz jar. Manufacturer identifies this as a prescription equine product and DEA List One Chemical. An FDA approval number has not been verified. Reviewed September 18, 2026. Manufacturer label: https://www.neogen.com/4a6b8d/globalassets/pim/assets/original/10023/08874_726087089744_tri-hist-granules_en-us.pdf

Sanctioning-body comparison

Plasma only. Compare published competition guidance for this medication. ESC guidance remains in Medication Facts above. A dosing guideline, withdrawal recommendation and laboratory detection threshold are different measures.

Sources reviewed September 23, 2026. “Not verified” means a gap in this comparison, not zero tolerance or permission. Doses describe the cited rules; your veterinarian must determine treatment and withdrawal.

Published guidance by organization
OrganizationPublished dose & routePlasma concentrationWithdrawal / timingControl / penalty class
AQHA Show HorsesShow rules · 2026 handbook
Conditions & sources

An unverified entry is not permission to use this medication. Consult the linked current rules.

Reviewed 2026-09-23

Not verified for this medication.Not verified for this medication.Not verified for this medication.Medication-specific control not yet verified.
APHA Paint Show HorsesShow rules · 2026 Rule Book
Conditions & sources

An unverified entry is not permission to use this medication. Consult the linked current rules.

Reviewed 2026-09-23

Not verified for this medication.Not verified for this medication.Not verified for this medication.Medication-specific control not yet verified.
ARCI Model RulesRacing model · Rules 15 / UCG 20.0 / CTMS 4.2.1
Conditions & sources

An unverified entry is not permission to use this medication. Consult the linked current rules.

Reviewed 2026-09-23

Not verified for this medication.Not verified for this medication.Not verified for this medication.Medication-specific control not yet verified.
USEFNational Therapeutic Substance Provisions · 2026 + July amendment
Conditions & sources

An unverified entry is not permission to use this medication. Consult the linked current rules.

Reviewed 2026-09-23

Not verified for this medication.Not verified for this medication.Not verified for this medication.Medication-specific control not yet verified.